New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations by Xiangyu Chen

Author:Xiangyu Chen
Language: eng
Format: epub
Publisher: Springer Singapore, Singapore

Entry

3.1a/3.2a

Solvent

Base

Yield (%)a

Ee (%)b

1

1.5/1

DCM

AcONa

33

99

2

1.5/1

DCM

AcONa

44c

99

3

1.5/1

DCM

AcONa

41d

99

4

1.5/1

CH3CN

AcONa

Trace

/

5

1.5/1

Toluene

AcONa

41

96

6

1.5/1

THF

AcONa

60

99

7

1.2/1

THF

AcONa

57

99

8

1/1.2

THF

AcONa

60

99

9

1/1.5

THF

AcONa

53

99

10

1/1.5

THF

K2CO3

81

99

11

1/1.1

THF

K 2 CO 3

82

99

12

1/1.0

THF

K2CO3

79

99

aIsolated yield

bDetermined by HPLC using a chiral stationary phase

cThe reaction was carried out at 30 °C

dThe reaction was carried out under reflux

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